Construction of a Phantom for Image Quality Evaluation in PET/MRI System

Abstract

Background: There is no phantom for image quality test in magnetic resonance imaging combined with positron emission tomography systems (PET/MRI systems). In MRI, radioactive water phantom containing 2-deoxy-2-[F-18] fluoro-D-glucose (¹⁸F-FDG) cannot be used due to the dielectric effect. Even for phantoms filled with MR-available solutions, the source current of the RF coil is strongly disturbed as the diameter of the phantom increases. Stable MR images require proper phantom size and solution selection. Previous reports have not provided these details. Other than that, few existing phantoms evaluate negative signals such as N-13 ammonia (¹³N-NH₃). We created a phantom for PET/MRI system for image quality test.
Methods: The phantom for the PET/MRI system was assembled in two portions. One portion is a signal part containing ¹⁸F-FDG radioactive water. The other portion is filled with polyvinyl alcohol glue to construct MRI image to generate μ-map. The glue part is allowed to rewrite the table position overlaps with the first layer, and attenuation correction is performed. Signals are set as positive (4 times and twice higher than background radioactivity) and negative (no radioactivity) columns with different sizes (15 mm φ and 7 mm φ). The PET images with X-ray computed tomography-based attenuation correction (CT-AC) and MRI-AC were evaluated by %-contrasts, variation and uniformity.
Results: The %-contrasts of the positive shallow signals with PET/magnetic resonance (MR) and PET/CT were 41.8% and 45.4%, respectively. And it of the positive deep signals with PET/MR and PET/CT were 40.7% and 44.9%. On the other hand, the %-contrasts of the negative shallow signals with PET/MR and PET/CT were 62.3% and 65.6%, respectively. And it of the negative deep signals with PET/MR and PET/CT were 60.7% and 63.7%. Moreover, the% Nj index of uniformity was 2.0% on PET / MRI images and 0.34% on PET / CT images. For negative signals that assume a decrease in myocardial blood flow, The image quality of MR-AC was almost the same as that of CT-AC. Consistency between the images after CT-AC and MR-AC correction were confirmed, and in particular, a stable MR-AC μ-map was obtained in the phantom study.
Conclusion: The suggested prototype phantom for generating μ-map is reasonable and useful for evaluating PET/MRI image quality, based on the present standard.