2022 Volume 59 Issue 1 Pages 60-71
Human papilloma virus vaccination associated neuro-immunopathic syndrome (HANS) is characterized by environmental hypersensitivity. We conducted an unparalleled follow-up of 8.5 years after the initial HPV vaccination. In HANS patients who could be followed for 8.5 years after the initial HPV vaccination, ADL (activities of daily living) worsened the most at 3.5 to 4 years, and 29% of patients wore sunglasses for photosensitivity during the same period. Autonomic function tests in the ADL severe group showed a significant decrease in parasympathetic function, and vascular endothelial function tests showed a decrease in function. In a case of HANS with severe environmental hypersensitivity, paroxysmal abnormal movements, tachycardia, pupillary mydriasis, and blood glucose dysregulation were prominent, and the symptoms were temporarily improved by treatment for cerebrospinal fluid leak and immunotherapy. Telomere G-tails were shortened in all 10 patients tested, and microRNA testing showed a high risk of cervical and breast cancer in 4 of 8 patients. HANS is a hypothalamic stress intolerance and fatigue syndrome associated with vascular endothelial damage caused by virus-like particles and chromosomal and microRNA abnormalities. This study is the first in the world to report that patients with HANS have chromosomal and microRNA abnormalities. The spectrum of other diseases presenting with the same condition and the causes of environmental hypersensitivity are also discussed.
