Abstract
There are various types of environmental stress to which humans are exposed: physical sensory stress (light, sound), chemical sensory stress (smell, chemicals), immune-coagulative stress, psychosocial stress, and internal environmental stress. Environmental stress hypersensitivity or intolerance is defined as a condition in which the body exhibits hypersensitivity of the stress sensory input system or insufficiency of the stress response output system to various environmental stresses, and as manifestation of hypothalamic stress intolerant and exhaustive syndrome or periventricular organ dysregulation syndrome, with multilayered autonomic, endocrine, and immunological symptoms, as well as a variety of systemic symptoms such as pain, fatigue, and memory impairment. Two types of environmental stress hypersensitivity or intolerance exist: idiopathic type with no apparent underlying diseases, and symptomatic type with apparent underlying diseases, such as myalgic encephalomyelitis and chronic fatigue syndrome, cerebrospinal fluid leak, HPV vaccination sequelae, COVID-19 chronic sequelae, sick house syndrome, and exposure to neonicotinoid insecticides. The pathogenesis and prevention of the disease were discussed, based on the 3-stage hypothesis. In the first genetic stage, genetic factors should control the ease or difficulty of developing environmental stress sensitivity or intolerance. In the second onset stage, the patient is exposed to environmental factors, and develops a constitutional tendency to be sensitive or intolerant to environmental stress, becoming a susceptible person. In the third trigger stage, environmental stress at a daily level, which is not bothering normal people at all, becomes a trigger factor for excessive stress sensitivity or intolerance, and the person becomes a sensitive or intolerant person.
