Treatment for circadian rhythm disorders caused by orthostatic dysregulation

Abstract

A questionnaire survey of school nurses revealed that there was a problem in which children and students with orthostatic control disorder were unable to sleep at night and wake up in the morning. The true cause of orthostatic dysregulation in sleep medicine is thought to be a state in which the body clock has moved significantly backwards and become fixed. Ramelteon has been used for treatment with Western medicine, but in recent years, melatonin and aripiprazole have been used. Administration of these Western medicines may be restricted due to medical insurance. The results of animal experiments suggest that the Chinese herbal medicine Yokukansanka Chenpihanxia may be effective on its own against circadian rhythm disorders by increasing endogenous melatonin levels.