BIOLOGICAL STUDIES ON FORMYCIN AND FORMYCIN B

抄録

The antitumor effect, distribution among various organs and toxicity of formycin and formycin B are studied. Formycin inhibits of Ehrlich carcinoma and L-1210, with stronger activity on the solid form than on the ascites form. Formycin B shows no inhibition of Ehrlich carcinoma or L-1210. The distribution among various organs of mice was examined after subcutaneous injection with ³H-formycin or ³H-formycin B. On the basis of radioactivity, formycin shows high concentrations in spleen and kidney, and formycin B is found in peritoneum, urinary bladder, kidney and spleen. By testing the effect on X. oryzae, low antibacterial activity was shown in various organs. When the lethal dose of formycin was injected in dogs, liver damage was found. Formycin B gives a marked reduction in white blood cells, though this reduction is recovered.