抄録
A rapid mobilization of enduracidin, introduced into the circulation, to each tissue was suggested from the results of intravenous injection and constant infusion studies in which blood levels and excretion into urine and bile were observed. Following intramuscular injection of 2 mg/kg of enduracidin, a plateau in the blood level (approximately 4 mcg/ml) was reached at 2 hours after the injection and this persisted for the next 2 hours and then decreased gradually. Increase in the dose resulted in the prolongation of the plateau, rather than a further rise in the maximum blood level. Except for the brain, enduracidin was found to distribute widely in the tissues including heart, lung, liver, spleen, adrenal, kidney, testis and muscle. Among these tissues, lung, liver, spleen and kidney contained higher concentrations of enduracidin than others, and in the case of multiple daily intramuscular injections, a parallel was noted in tissue enduracidin levels with doses and number of injections, with the exception of kidney. Enduracidin, once transported to the tissues, was retained for rather long period of time in the liver, and except for the kidney, presumably in other tissues. Enduracidin may be excreted mainly via urinary excretion.
