Abstract
An antibiotic weakly active against Candida was isolated as a colorless crystalline hydrochloride from a culture of a streptomyces which showed some resemblances with Streptomyces eurythermits. This antibiotic was unstable to acid and alkali, but was recovered in good yield by elution with 0.5M ammoniumchloride solution from the ion-exchange resin, Amberlite IRC-50 (Na+ type). It was determined to be acrylamidine by spectroscopic data, degradation and direct comparison with a synthetic sample. The LD50 (mice) of acrylamidine was 44 mg/kg intravenously.
