STUDIES ON SIOMYCIN. V

DERIVATIVES OF SIOMYCIN A PREPARED WITH THIOLCARBOXYLIC ACID

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Derivatives of siomycin A were prepared by reaction with thiolcarboxylic acids such as thioglycolic acid or thiomalic acid. Sodium salts of the derivatives were remarkably soluble in water, while the parent siomycin A was quite insoluble. These " soluble derivatives " of the antibiotic were still active against many Gram-positive bacteria, although the activities were approximately one fifth of that of siomycin A.