STUDIES ON THE EFFECT OF ADMINISTRATION OF TETRACYCLINE ON FREE FATTY ACID METABOLISM IN ADRENALECTOMISED AND CONTROL RATS

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Administration of therapeutic doses of tetracycline hydrochloride to rats results in increased accumulation of triglyceride in the liver. Phospholipid concentration of the liver is decreased under such conditions, whereas both free and esterified cholesterol levels remain unaffected. Elevation of the free fatty acid level of plasma, induced by tetracycline administration, is due to increased mobilisation of free fatty acids from adipose tissue. The antibiotic was found to be ineffective in stimulating the mobilisation of free fatty acids from the epididymal fatpad of adrenalectomised rats.