STUDIES ON THE ANTIBIOTICS FROM STREPTOMYCES SPINICHROMOGENES VAR. KUJIMYCETICUS. II ISOLATION AND CHARACTERIZATION OF KUJIMYCINS A AND B

SADAFUMI OMURA; SHINJURO NAMIKI; MICHINORI SHIBATA; TOSHIO MURO; HIROSHI NAKAYOSHI; JIRO SAWADA

doi:10.7164/antibiotics.22.500

STUDIES ON THE ANTIBIOTICS FROM STREPTOMYCES SPINICHROMOGENES VAR. KUJIMYCETICUS. II

ISOLATION AND CHARACTERIZATION OF KUJIMYCINS A AND B

SADAFUMI OMURA, SHINJURO NAMIKI, MICHINORI SHIBATA, TOSHIO MURO, HIROSHI NAKAYOSHI, JIRO SAWADA

著者情報

ジャーナルフリー

1969 年 22 巻 10 号 p. 500-505

DOI https://doi.org/10.7164/antibiotics.22.500

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抄録

Two new antibiotics, kujimycins A and B, were isolated from the fermentation broth of Streptomyces sp. TPR-885 and purified by the extraction with ethyl acetate, gel filtration on Sephadex LH-20 and silica gel column chromatography. Kujimycin A was obtained as colorless powder, m. p. 114-115°C, C₄₀H₇₀O₁₅. Kujimycin B was obtained as colorless prisms, m.p. 178-180°C, C₄₂H₇₂O₁₆. They were suggested to be neutral macrolides which have antimicrobial activities against Gram-positive bacteria.

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