Abstract
A new crystalline anti-tumor agent, compound 593A, has been discovered in fermentation broths of Streptomyces griseoluteus. Its presence in the fermented broth was detected by the human tumor-egg host system which was used also to help guide fermentation and isolation studies. On a weight basis, against the human adenocarcinoma (H. Ad.) # 1 in the embryonated egg, antitumor compound 593A is about 100 times as potent as hadacidin, about 4 times as potent as sodium L-tenuazonate, and about one-half as potent as mitomycin C . It also inhibits, in the egg, growth of the humansarcoma(H. S.)#1, and metastasis but not primary growth of the human epidermoid carcinoma (H. Ep.) #3. Anti-tumor compound 593A has the empirical formula C7H11ON2Cl.
