抄録
Megalomicin (MM), one of the macrolide antibiotics, has a lactone structure similar to erythromycin (EM). The antibacterial activity of MM toward Staphylococcus aureus was compared with that of EMusing macrolide-sensitive and resistant strains of clinical origin. The antibacterial activity of MMwas found to be slightly weaker than that of EMand the strains carrying macrolide-constitutive resistance were also resistant to MM.It was found that MM is an active inducer for macrolide resistance in the strains harboring macrolide-inducible resistance, in which only EM and both EM and oleandomycin were active inducers. Induction ability of MM and induction mechanisms for macrolide resistance are discussed.
