ANTIBIOTICS PRODUCED BY STREPTOMYCES. VII

CYTOTETRIN, A NEW ANTITUMOR ANTIBIOTIC

Abstract

From the culture broth of Streptomyces griseoflavus a new orange red basic antibiotic named cytotetrin complex was isolated by solvent extraction. The complex was fractionated into five active components, cytotetrins A, B, C, D and E, respectively. The physical, chemical and biological properties of each cytotetrin are discussed. They are active against Gram-positive microorganisms and some tumors. Cytotetrin is related to nogalamycin.