The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
MELINACIDINS, A NEW FAMILY OF ANTIBIOTICS
A. D. ARGOUDELISF. REUSSER
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1971 Volume 24 Issue 6 Pages 383-389

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Abstract

Melinacidin is a crystalline mixture of closely related antibacterial agents produced by Acrostalagmus cinnabarinus var. melinacidinus. Melinacidin inhibits a variety of Gram-positive bacteria in vitro but is found to be toxic and ineffective in the treatment of experimental bacterial infections in mice. Melinacidin which inhibits the growth of KB and L-1210 cells in tissue culture appears to belong to the "3, 6-epidithiadiketopiperazine" group of antibiotics.

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