抄録
Carbenicillin is capable of inactivating gentamicin in vitro. This effect is time, temperature and medium dependent. In vitro antibacterial tests demonstrate greater than additive activity in some instances and inactivation in others, particularly after prolonged incubation. Inactivation was not observed in vivo in mouse protection tests. Additive or more than additive combined activity in mouse protection tests occurred only infrequently. Intravenous administration of carbenicillin had no effect on gentamicin serum levels (given i.m.) in dogs although it did result in reduced recovery of gentamicin in the urine. This may have occurred after the urine had left the bladder. It is important that serum samples containing both gentamicin and carbenicillin be assayed shortly after drawing since inactivation can occur in these samples which then might be falsely interpreted as in vivo inactivation.
