The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
METABOLIC PRODUCTS OF MICROORGANISMS 116
O-[L-NORVALYL-5]-ISOUREA, A NEW ARGININE ANTAGONIST
W. A. KÖNIGH. KNEIFELE. BAYERG. MÜLLERH. ZÃHNER
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1973 Volume 26 Issue 1 Pages 44-50

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Abstract

From a bacterial culture a new antibiotic, O-[L-norvalyl-5]-isourea, was isolated. The structure was determined by mass spectrometry and confirmed by chemical synthesis. The antibiotic activity is inhibited by L-arginine, L-ornithine and L-citrulline.

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