A new antibiotic, designated X-5108, produced by a new species of microorganism named
Streptomyces goldiniensis var.
goldiniensis, has been isolated in essentially pure but amorphous form. Assay methods, and cultivation and isolation procedures for the antibiotic are described. The antibiotic is active
in vitro primarily against a number of gram-positive bacteria, whereas
in vivo it is especially active against
Streptococcus pyogenes infections of mice and as a poultry growth promotant. It shows a very low toxicity in mice with an LD
50 of >lg/kg sbc, and >4 g/kg p.o. Its empirical formula is C
44H
62N
2O
12. Structural studies reveal one methoxyl, one N-methyl and six C-methyl groups. UV, IR and NMR spectra and optical rotation of the pure antibiotic are given. The antibiotic appears to belong to a new chemical class.
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