ISOLATION AND GROSS STRUCTURE OF A NEW ANTIBIOTIC SS-56 C AND RELATED COMPOUNDS

Abstract

A new antibiotic, designated SS-56 C, has been isolated from a culture broth of Streptomyces eurocidicus No. SS-56. The antibiotic is active against a number of Gram-positive, negative bacteria and fungi. Structural studies including analysis of NMR and in particular MS spectra and acid degradation suggested that SS-56 C substance is the 2-hydroxy derivative of A-396-I substance. Together with SS-56 C substance, were isolated two new hexoglycosides of 2-deoxystreptamine (SS-56 A and B), as well as A-396-I substance (SS-56 D), and gross structures were deduced.