IMMUNOLOGICAL CROSS-REACTIONS OF SULFOBENZYLPENICILLIN

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Sulfobenzylpenicillin (sulbenicillin)-BGG conjugate was shown to be highly reactive with anti-sulbenicillin-BSA serum. This conjugate was, however, not reactive or was only slightly reactive with anti-benzylpenicillin- and anti-ampicillin-BSA sera produced in rabbits. The immunological specificity of sulbenicillin seems to be dependent on the acyl side chain of the molecule, while, its immunological cross-reactivity seems to be dependent on the 6-aminopenicillanic acid moiety in the structure of penicillin. Also, with other penicillin derivatives, similar evidence was obtained. Immunodiffusion studies revealed that two precipitin bands developed between several penicillin-BGG conjugates and anti-penicillin-BSA serum. Since these precipitin bands do not correlate with BGG and BSA used as carrier, the bands are probably formed by the specific immunological reaction between penicillin and anti-penicillin serum. Furthermore, specific reactivity of sulbenicillin is also demonstrated by the development of passive cutaneous anaphylaxis test.