A FLUOMETRIC DETERMINATION OF HISTAMINE UPON THE ADMINISTRATION OF MACROLIDE ANTIBIOTICS

Abstract

The administration of the macrolide antibiotics, oleandomycin, spiramycin anderythromycin, caused marked depressor effect and increased histamine content inthe blood. Histamine in the blood was measured by colorimetry, fluorometry andbioassay. As method of measurement of minute quantities of histamine, fluorometryand bioassay were superior, and the technic of fluorometry was most simple.