STUDIES ON LANKACIDIN-GROUP (T-2636) ANTIBIOTICS. IX
PREPARATION OF 14C-LABELED LANKACIDIN C 14-PROPIONATE
1975 年 28 巻 1 号 p. 15-20
詳細
1975 年 28 巻 1 号 p. 15-20
To investigate the metabolic fate of lankacidin C 14-propionate in experimental animals, the 14C-labeled antibiotic was prepared by the fermentation of Streptomyces rochei var. volubilis in the presence of various 14C-labeled organic carboxylic acids, amino acids and carbohydrates. Significant incorporation (20-40%) was observed with L-methionine-methyl-14C. Lankacidin C 14-propionate-14C (specific activity 49.6 μCi/mg) was obtained from lankacidin C-14C and ethyl propionate by the action of an acylase of the streptomyces.
