Abstract
5"-Amino-3', 4', 5"-trideoxybutirosin A (IX) was synthesized through a reaction series starting from 5"-amino-5"-deoxybutirosin A (Ic), the key step being the treatment of its tetra-O-acetylpentakis-N-[(phenylmethoxy)carbonyl]-3', 4'-bis-O-(methylsulfonyl) derivative (VI) with zinc-sodium iodide. Compound IX exhibits enhanced antibacterial activities, including strains of Pseudomonas aeruginosa and Escherichia coli which are highly resistant to Ic, butirosin or gentamicin.
