NEW ISOFLAVONES, INHIBITING CATECHOL-O-METHYLTRANSFERASE, PRODUCED BY STREPTOMYCES

HIDEO CHIMURA; TSUTOMU SAWA; YOSHIKI KUMADA; HIROSHI NAGANAWA; MEIKI MATSUZAKI; TOMOHISA TAKITA; MASA HAMADA; TOMIO TAKEUCHI; HAMAO UMEZAWA

doi:10.7164/antibiotics.28.619

NEW ISOFLAVONES, INHIBITING CATECHOL-O-METHYLTRANSFERASE, PRODUCED BY STREPTOMYCES

HIDEO CHIMURA, TSUTOMU SAWA, YOSHIKI KUMADA, HIROSHI NAGANAWA, MEIKI MATSUZAKI, TOMOHISA TAKITA, MASA HAMADA, TOMIO TAKEUCHI, HAMAO UMEZAWA

著者情報

ジャーナルフリー

1975 年 28 巻 9 号 p. 619-626

DOI https://doi.org/10.7164/antibiotics.28.619

詳細

抄録

In the screening of catechol-O-methyltransferase inhibitors in streptomyces culture filtrates, three new isoflavones were isolated. Their structures were shown to be 3', 5, 7-trihydroxy-4', 6-dimethoxyisoflavone (I), 3', 5, 7-trihydroxy-4', 8-dimethoxyisoflavone (II), 3', 8-dihydroxy-4', 6, 7-trimethoxyisoflavone (III). I and II inhibited both catechol-O-methyltransferase and dopa decarboxylase, and showed hypotensive action. III was a specific inhibitor of catechol-O-methyltransferase, and showed no hypotensive action.

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