A NEW ANTIBIOTIC, FUMARAMIDMYCIN II. ISOLATION, STRUCTURE AND SYNTHESES

YASUJI SUHARA; HIROMI B. MARUYAMA; YOSHIAKI KOTOH; YUMIKO MIYASAKA; KAZUTERU YOKOSE; HARUYOSHI SHIRAI; KOUICHI TAKANO

doi:10.7164/antibiotics.28.648

A NEW ANTIBIOTIC, FUMARAMIDMYCIN

II. ISOLATION, STRUCTURE AND SYNTHESES

YASUJI SUHARA, HIROMI B. MARUYAMA, YOSHIAKI KOTOH, YUMIKO MIYASAKA, KAZUTERU YOKOSE, HARUYOSHI SHIRAI, KOUICHI TAKANO

著者情報

ジャーナルフリー

1975 年 28 巻 9 号 p. 648-655

DOI https://doi.org/10.7164/antibiotics.28.648

詳細

抄録

A new antibiotic fumaramidmycin produced by Streptomyces kurssanovii NR-7GGl was isolated as colorless crystals. The structure was shown to be N-(phenylacetyl) fumaramide. Starting from fumaramic acid, fumaramidmycin has been synthesized in good yield, in which the key stage involves N-acylated imino ether formation followed by mild acid hydrolysis. Five analogues of fumaramidmycin have also been prepared.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）