A NEW ANTIBIOTIC, ASUKAMYCIN, PRODUCED BY STREPTOMYCES

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Asukamycin, a new antibiotic, has been isolated from the culture broth of a streptomycete designated as Streptomyces nodosus subsp. asukaensis. The antibiotic inhibits the growth of Gram-positive bacteria including Nocardia asteroides. The empirical formula of
antibiotic asukamycin has been proposed as C₂₉H₂₂N₂O₉ (M.W. 542). An acute toxicity of the antibiotic in mice is LD₅₀ 48.5 mg/kg by intraperitoneal injection and it has no effect on mice when it was administered by 450 mg/kg per os.