TALLYSOMYCIN, A NEW ANTITUMOR ANTIBIOTIC COMPLEX RELATED TO BLEOMYCIN

I. PRODUCTION, ISOLATION AND PROPERTIES

Abstract

The unusual actinomycetes strain No. E465-94 produced a complex of new glycopeptide antibiotics tallysomycin, which was separated by CM-Sephadex chromatography into two major components, A (C₆₈H₁₀₇N₂₁O₂₇S₂) and B (C₆₂H₉₅N₁₉O₂₆S₂). They were isolated first in a copperchelated form and showed physico-chemical properties similar to those of the bleomycingroup of antibiotics. Tallysomycin exhibited broad antibacterial and antifungal activity, and was highly active in vivo against bacterial infections in mice. Tallysomycins A and B demonstrated potent activity in the prophage induction of lysogenic bacteria.