The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
THE AMINOGLYCOSIDE ANTIBIOTICS
I. SYNTHESIS AND BIOLOGICAL EVALUATION OF AN ANALOG OF GENTAMICIN
ROBERT D. SITRINDAVID J. COOPERJERRY A. WEISBACH
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1977 年 30 巻 10 号 p. 836-842

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The synthesis of 2-deoxy-4-O-(2, 6-diamino-2, 3, 4, 6-tetradeoxy-α-D-erythrohexopyranosyl)-6-O-(3-deoxy-3-methylamino-α-D-xylopyranosyl)-D-streptamine (1), an analog of gentamicin A, from dideoxyneamine and methyl 3-methylamino-3-deoxy-β-D-xylopyranoside is described. The product was characterized by its 13C nmr spectrum and was found to exhibit broad spectrum antibacterial activity.
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© Japan Antibiotics Research Association
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