The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
SYNTHESIS AND ANTIBACTERIAL ACTIVITIES OF 1-N [(S)- ω-AMINO-2-HYDROXYALKYL] KANAMYCIN A DERIVATIVES
K. RICHARDSONS. JEVONSJ. W. MOOREB. C. RossJ. R. WRIGHT
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1977 Volume 30 Issue 10 Pages 843-846

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Abstract

Four 1-N-aminohydroxy-alkyl derivatives of kanamycin A were prepared and their in vitro activities against aminoglycoside-sensitive and aminoglycoside-resistant organisms were compared with amikacin. 1-N-[(S)-4-Amino-2-hydroxybutyl] kanamycin A (Fig. 1, compound 2, code no. UK-18, 892) was equipotent to amikacin in all these tests and in mouse protection studies.

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