抄録
Chemical and photochemical oxidative methods of de-N-methylation of some gentamicins and sisomicins at the 3"-position are described. Selective acetylation of gentamicins and sisomicins at the 1, 3, 2' and 6' and of gentamicin B at the 1, 3, and 6' positions are achieved by treatment of the free bases with carbon dioxide prior to acetylation. De-N-methylation of the above selectively blocked gentamicins and sisomicins followed by re-alkylation at the 3"-position and de-N-protection gives a series of 3"-N-alkyl analogues. The in vitro antibacterialproperties of the new derivatives of gentamicins and sisomicins are given.
