ACTION OF CEFOXITIN AND CEFAMANDOLE ON HUMAN NEUTROPHIL FUNCTION
1978 年 31 巻 10 号 p. 1059-1062
詳細
1978 年 31 巻 10 号 p. 1059-1062
Polymorphonuclear neutrophilic leukocyte chemotaxis was examined in vitro in the presence of two new antibiotics: cefamandole and cefoxitin. Results indicate that cefamandole inhibited neutrophil chemotaxis to a significant degree only at high antibiotic concentrations of 100 μg/ml (P<0.01) and has no significant effect at normal serum therapeutic range. Cefoxitin was found to produce a 43% inhibition (P<0.01) of human in vivo neutrophil chemotaxis at antibiotic concentrations of 100 μg/ml and have a minimal inhibitory effect (1-9%) at low concentrations (1-5 μg/ml). Both cefamandole and cefoxitin had no significant effect on opsonophagocytosis.
