NEW ANTIBIOTICS FROM THE FUNGUS EPICOCCUM NIGRUM

II. EPICORAZINE A: STRUCTURE ELUCIDATION AND ABSOLUTE CONFIGURATION

Abstract

An antibiotic, epicorazine A, isolated from a particular strain of the fungus Epicoccum nigrum, was shown to be a new epidithiodiketopiperazine from its UV, IR, mass, NMR and CD spectra. X-Ray diffraction measures confirmed this structure and its absolute configuration.