NEW ANTIBIOTICS FROM THE FUNGUS EPICOCCUM NIGRUM

III. EPICORAZINE B: STRUCTURE ELUCIDATION AND ABSOLUTE CONFIGURATION

Abstract

Comparison of UV, IR, PMR and CD spectra of epicorazine B with those of epicorazine A, a previously isolated metabolite of Epicoccum nigrum, showed that they were isomers with the same epidithiodiketopiperazine skeleton. X-Ray determination of epicorazine B indicated that the difference is related to a cis-trans configuration.