BIOCHEMICAL ACTIVITIES OF THE DERIVATIVES OF DEHYDRODICAFFEIC ACID DILACTONE

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Activities of derivatives of dehydrodicaffeic acid dilactone (DDCAD) to inhibit catechol-O-methyltransferase (COMT), cyclic AMP phosphodiesterase (PDE) and DOPA decarboxylase(DDC) were examined. Among those tested, 2, 6-bis-(5', 6'-dibromo-4'-hydroxy-3'-methoxyphenyl)-3, 7-dioxabicyclo-[3, 3, 0]-octane 4, 8-dione was found to be the strongestinhibitor of both COMT and PDE. There were no derivatives which showed a strongerinhibition against DDC than the original compound, DDCAD.