1-N HAPA GENTAMICIN B, A NEW AMINOGLYCOSIDE ACTIVE AGAINST GENTAMICIN RESISTANT ISOLATES-ACTIVITY COMPARED TO OTHER AMINOGLYCOSIDES
1978 年 31 巻 5 号 p. 385-393
詳細
1978 年 31 巻 5 号 p. 385-393
1-N HAPA gentamicin B is a new aminoglycoside active against most Enterobacteriaceae, Pseudomonas aeruginosa and Staphylococcus aureus. Among 504 clinical isolates at a concentration of 12.5 μg/ml all Staph. aureus, Escherichia coil, Klebsiella, Enterobacter, Proteus
rettgeri, Providencia and 78% of Pseudomonas, 86% of Proteus morganii were inhibited. Like other aminoglycosides, the activity was greatest at an alkaline pH and reduced by high cations concentrations. 1-N HAPA gentamicin B was equal in activity to amikacin against
both gentamicin-sensitive and resistant isolates. It inhibited bacteria containing many of the aminoglycoside inactivating enzymes. When combined with carbenicillin it inhibited in a synergistic manner many Gram-negative bacteria, particularly Pseudomonas and Serratia.
