GLOBOMYCIN, A NEW PEPTIDE ANTIBIOTIC WITH SPHEROPLAST-FORMING ACTIVITY III. STRUCTURAL DETERMINATION OF GLOBOMYCIN

MUTSUO NAKAJIMA; MASATOSHI INUKAI; TATSUO HANEISHI; AKIRA TERAHARA; MAMORU ARAI; TAKESHI KINOSHITA; CHIHIRO TAMURA

doi:10.7164/antibiotics.31.426

GLOBOMYCIN, A NEW PEPTIDE ANTIBIOTIC WITH SPHEROPLAST-FORMING ACTIVITY

III. STRUCTURAL DETERMINATION OF GLOBOMYCIN

MUTSUO NAKAJIMA, MASATOSHI INUKAI, TATSUO HANEISHI, AKIRA TERAHARA, MAMORU ARAI, TAKESHI KINOSHITA, CHIHIRO TAMURA

著者情報

ジャーナルフリー

1978 年 31 巻 5 号 p. 426-432

DOI https://doi.org/10.7164/antibiotics.31.426

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抄録

The structure of globomycin has been determined by mass, PMR and CMR spectra and by chemical degradation. Globomycin is a new cyclic peptide antibiotic composed of L-serine, L-allo-threonine, glycine, N-methylleucine, L-allo-isoleucine and 3-hydroxy-2-methyl-nonaic acid. Among these components, L-allo-threonine, L-allo-isoleucine and 3-hydroxy-2-methylnonaic acid are novel components from natural products. A newly developed mass analysis has been introduced for determining the diastereoisomers of allo-threonine.

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