MODIFICATION OF SELDOMYCIN FACTOR 5 AT C-3'

RONALD E. CARNEY; JAMES B. MCALPINE; MARIANNA JACKSON; RUTH S. STANASZEK; WILLIAM H. WASHBURN; MOMIR CIROVIC; SANDRA L. MUELLER

doi:10.7164/antibiotics.31.441

RONALD E. CARNEY, JAMES B. MCALPINE, MARIANNA JACKSON, RUTH S. STANASZEK, WILLIAM H. WASHBURN, MOMIR CIROVIC, SANDRA L. MUELLER

著者情報

RONALD E. CARNEY
Division of Antibiotics and Natural Products Pharmaceutical Products Research and Development Abbott Laboratories
JAMES B. MCALPINE
Division of Antibiotics and Natural Products Pharmaceutical Products Research and Development Abbott Laboratories
MARIANNA JACKSON
Division of Antibiotics and Natural Products Pharmaceutical Products Research and Development Abbott Laboratories
RUTH S. STANASZEK
Division of Antibiotics and Natural Products Pharmaceutical Products Research and Development Abbott Laboratories
WILLIAM H. WASHBURN
Division of Antibiotics and Natural Products Pharmaceutical Products Research and Development Abbott Laboratories
MOMIR CIROVIC
Division of Antibiotics and Natural Products Pharmaceutical Products Research and Development Abbott Laboratories
SANDRA L. MUELLER
Division of Antibiotics and Natural Products Pharmaceutical Products Research and Development Abbott Laboratories

ジャーナルフリー

1978 年 31 巻 5 号 p. 441-450

DOI https://doi.org/10.7164/antibiotics.31.441

詳細

抄録

Attempted removal of the 3'-hydroxyl group of seldomycin factor 5 via displacement of a sulfonate ester has led to 3'-epi-seldomycin factor 5. Removal of the hydroxyl group has been effected by the BARTON procedure. The antibacterial activity of 3'-epi- and 3'-deoxyseldomycin factor 5 against various aminoglycoside-resistant strains is discussed.

責任著者(Corresponding author)

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