The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
AMINOGLYCOSIDE ANTIBIOTICS. XII
EFFECT OF N-ALKYLATION IN KANAMYCIN ANTIBIOTICS
SUSUMU NAKAGAWA, SOICHIRO TODA, YOSHIO ABE, HARUHIRO YAMASHITA, KEI-ICHI FUJISAWA, TAKAYUKI NAITO, HIROSHI KAWAGUCHI
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1978 Volume 31 Issue 7 Pages 675-680

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Abstract

Four N-ethyl derivatives of kanamycin A and five N-ethyl derivatives of kanamycin B were synthesized. The antimicrobial activity of N-ethyl kanamycin derivatives was determined against aminoglycoside-sensitive and resistant organisms. The structure-activity relationship of these compounds is discussed with reference to the activity of N-acyl kanamycin derivatives.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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