ISOLATION AND STRUCTURE ELUCIDATION OF A NOVEL GRISEORHODIN

RONALD M. STROSHANE; JAMES A. CHAN; ELIZABETH A. RUBALCABA; ALINE L. GARRETSON; ADORJAN A. ASZALOS; PETER P. ROLLER

doi:10.7164/antibiotics.32.197

RONALD M. STROSHANE, JAMES A. CHAN, ELIZABETH A. RUBALCABA, ALINE L. GARRETSON, ADORJAN A. ASZALOS, PETER P. ROLLER

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ジャーナルフリー

1979 年 32 巻 3 号 p. 197-204

DOI https://doi.org/10.7164/antibiotics.32.197

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Three antibiotics possessing cytotoxic properties were isolated from a strain of Streptomyces griseus (FCRC-57). One was found to be identical with griseorhodin A.^2-6) A second, FCRC-57-U, was found to be identical to griseorhodin C⁷⁾. FCRC-57-G is a new antibiotic structurally related to griseorhodins A and C, and is active against KB cells in vitro. The structure of this new antibiotic was determined using mass spectrom/etry, proton and carbon nuclear magnetic resonance spectroscopy and synthesis.

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