γ-CHLORONORVALINE, A LEUCINE ANALOG FROM STREPTOMYCES

S. NARAYANAN; M. R. S. IYENGAR; P. L. GANJU; S. RENGARAJU; TAKASHI SHOMURA; TAKASHI TSURUOKA; SHIGEHARU INOUYE; TARO NIIDA

doi:10.7164/antibiotics.33.1249

γ-CHLORONORVALINE, A LEUCINE ANALOG FROM STREPTOMYCES

S. NARAYANAN, M. R. S. IYENGAR, P. L. GANJU, S. RENGARAJU, TAKASHI SHOMURA, TAKASHI TSURUOKA, SHIGEHARU INOUYE, TARO NIIDA

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ジャーナルフリー

1980 年 33 巻 11 号 p. 1249-1255

DOI https://doi.org/10.7164/antibiotics.33.1249

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抄録

γ-Chloronorvaline (AL-719) and γ-hydroxynorvalinelactone (AL-719Y) were isolated from the culture broth of Streptomyces griseosporeus AL-719. Physico-chemical studies led to the structure elucidation of AL-719 and 719Y, with their respective configurations of (2S, 4S) and
(2S, 4R). AL-719 shows antibacterial activity on a synthetic agar, especially against Pseudomonas aeruginosa, which was reversed by L-leucine. The producing strain AL-719 was characterized.

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