FR-900148, A NEW ANTIBIOTIC I. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION

YOSHIO KURODA; MASAKUNI OKUHARA; TOSHIO GOTO; MICHIO YAMASHITA; EIKO IGUCHI; MASANOBU KOHSAKA; HATSUO AOKI; HIROSHI IMANAKA

doi:10.7164/antibiotics.33.259

FR-900148, A NEW ANTIBIOTIC

I. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION

YOSHIO KURODA, MASAKUNI OKUHARA, TOSHIO GOTO, MICHIO YAMASHITA, EIKO IGUCHI, MASANOBU KOHSAKA, HATSUO AOKI, HIROSHI IMANAKA

著者情報

ジャーナルフリー

1980 年 33 巻 3 号 p. 259-266

DOI https://doi.org/10.7164/antibiotics.33.259

詳細

抄録

A strain of Streptomyces, isolated from a soil sample and identified as Streptomyce xanthocidicus, has been found to produce FR-900148, a new antibiotic containing chlorine in its molecule. The antibiotic inhibits both Gram-positive and negative bacteria. However, it is not effective against wild type of Pseudomonas aeruginosa. Its antibacterial action is considered to result from cell wall synthesis inhibition since it causes spheroplast formation from susceptible cells.

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