THE STRUCTURE OF LIENOMYCIN, A PENTAENE MACROLIDE ANTITUMOR ANTIBIOTIC II. THE LOCATION OF THE PENTAENE CHROMOPHORE AND OF SIX ISOLATED DOUBLE BONDS. THE COMPLETE STRUCTURE OF THE ANTIBIOTIC

J. PAWLAK; J. ZIELINSKI; J. GOLIK; E. JERECZEK; E. BOROWSKI

doi:10.7164/antibiotics.33.998

THE STRUCTURE OF LIENOMYCIN, A PENTAENE MACROLIDE ANTITUMOR ANTIBIOTIC

II. THE LOCATION OF THE PENTAENE CHROMOPHORE AND OF SIX ISOLATED DOUBLE BONDS. THE COMPLETE STRUCTURE OF THE ANTIBIOTIC

J. PAWLAK, J. ZIELINSKI, J. GOLIK, E. JERECZEK, E. BOROWSKI

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JOURNAL FREE ACCESS

1980 Volume 33 Issue 9 Pages 998-1004

DOI https://doi.org/10.7164/antibiotics.33.998

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Abstract

The locations of the isolated double bonds and of the pentaene chromophore in lienomycin (I) were established by chemical degradation of I followed by MS and ¹H NMR examination of the products. The complete structure of the antibiotic is proposed.

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