The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
TALLYSOMYCIN, A NEW ANTITUMOR ANTIBIOTIC COMPLEX RELATED TO BLEOMYCIN
IV. NEW BIOSYNTHETIC DERIVATIVES OF TALLYSOMYCIN
TAKEO MIYAKIOSAMU TENMYOKEI-ICHI NUMATAKIYOSHI MATSUMOTOHARUAKI YAMAMOTOYUJI NISHIYAMAMASARU OHBAYASHIHIDEYO IMANISHIMASATAKA KONISHIHIROSHI KAWAGUCHI
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1981 Volume 34 Issue 6 Pages 658-664

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Abstract
A series of new biosynthetic derivatives of tallysomycins A and B were obtained by precursor amine-feeding fermentation. Certain diamines were incorporated into tallysomycins as the terminal amine moiety affording two classes of biosynthetic derivatives, with or without the β-lysine moiety in the subterminal position. Among 21 derivatives prepared, tallysomycin S10b was selected for further studies in view of its favorable therapeutic indices.
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© Japan Antibiotics Research Association
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