TALLYSOMYCIN, A NEW ANTITUMOR ANTIBIOTIC COMPLEX RELATED TO BLEOMYCIN IV. NEW BIOSYNTHETIC DERIVATIVES OF TALLYSOMYCIN

TAKEO MIYAKI; OSAMU TENMYO; KEI-ICHI NUMATA; KIYOSHI MATSUMOTO; HARUAKI YAMAMOTO; YUJI NISHIYAMA; MASARU OHBAYASHI; HIDEYO IMANISHI; MASATAKA KONISHI; HIROSHI KAWAGUCHI

doi:10.7164/antibiotics.34.658

TALLYSOMYCIN, A NEW ANTITUMOR ANTIBIOTIC COMPLEX RELATED TO BLEOMYCIN

IV. NEW BIOSYNTHETIC DERIVATIVES OF TALLYSOMYCIN

TAKEO MIYAKI, OSAMU TENMYO, KEI-ICHI NUMATA, KIYOSHI MATSUMOTO, HARUAKI YAMAMOTO, YUJI NISHIYAMA, MASARU OHBAYASHI, HIDEYO IMANISHI, MASATAKA KONISHI, HIROSHI KAWAGUCHI

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JOURNAL FREE ACCESS

1981 Volume 34 Issue 6 Pages 658-664

DOI https://doi.org/10.7164/antibiotics.34.658

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Abstract

A series of new biosynthetic derivatives of tallysomycins A and B were obtained by precursor amine-feeding fermentation. Certain diamines were incorporated into tallysomycins as the terminal amine moiety affording two classes of biosynthetic derivatives, with or without the β-lysine moiety in the subterminal position. Among 21 derivatives prepared, tallysomycin S_10b was selected for further studies in view of its favorable therapeutic indices.

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