A NEW BROAD-SPECTRUM AMINOGLYCOSIDE ANTIBIOTIC COMPLEX, SPORARICIN IV. SPORARICINS C AND D

TAKEO DEUSHI; ISAMU WATANABE; AKIO IWASAKI; KAZUHIRO KAMIYA; TOSHIMI MIZOGUCHI; MASAHITO NAKAYAMA; MASAO OKUCHI; HISAKATSU ITOH; TOSHIHITO MORI

doi:10.7164/antibiotics.34.811

A NEW BROAD-SPECTRUM AMINOGLYCOSIDE ANTIBIOTIC COMPLEX, SPORARICIN

IV. SPORARICINS C AND D

TAKEO DEUSHI, ISAMU WATANABE, AKIO IWASAKI, KAZUHIRO KAMIYA, TOSHIMI MIZOGUCHI, MASAHITO NAKAYAMA, MASAO OKUCHI, HISAKATSU ITOH, TOSHIHITO MORI

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ジャーナルフリー

1981 年 34 巻 7 号 p. 811-817

DOI https://doi.org/10.7164/antibiotics.34.811

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抄録

Two new aminoglycoside antibiotics, sporaricins C and D have been isolated from the culture broth of Saccharopolyspora hirsuta subsp. kobensis, which produced sporaricins A and B. The structures of sporaricins C and D have been determined to be 4-N-carbamoylglycylsporaricin B and 4-N-formylglycylsporaricin B, respectively. Sporaricins C and D are active against Gram-positive and Gram-negative bacteria including aminoglycosideresistant strains.

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