STUDIES ON A NEW AMINOGLYCOSIDE ANTIBIOTIC, DACTIMICIN II. ISOLATION, STRUCTURE AND CHEMICAL DEGRADATION

KAZUNORI OHBA; TAKASHI TSURUOKA; KAZUKO MIZUTANI; NORIKO KATO; SHOJI OMOTO; NORIO EZAKI; SHIGEHARU INOUYE; TARO NIIDA; KOJI WATANABE

doi:10.7164/antibiotics.34.1090

STUDIES ON A NEW AMINOGLYCOSIDE ANTIBIOTIC, DACTIMICIN

II. ISOLATION, STRUCTURE AND CHEMICAL DEGRADATION

KAZUNORI OHBA, TAKASHI TSURUOKA, KAZUKO MIZUTANI, NORIKO KATO, SHOJI OMOTO, NORIO EZAKI, SHIGEHARU INOUYE, TARO NIIDA, KOJI WATANABE

Author information

KAZUNORI OHBA
Central Research Laboratories, Meiji Seika, Kaisha Ltd.
TAKASHI TSURUOKA
Central Research Laboratories, Meiji Seika, Kaisha Ltd.
KAZUKO MIZUTANI
Central Research Laboratories, Meiji Seika, Kaisha Ltd.
NORIKO KATO
Central Research Laboratories, Meiji Seika, Kaisha Ltd.
SHOJI OMOTO
Central Research Laboratories, Meiji Seika, Kaisha Ltd.
NORIO EZAKI
Central Research Laboratories, Meiji Seika, Kaisha Ltd.
SHIGEHARU INOUYE
Central Research Laboratories, Meiji Seika, Kaisha Ltd.
TARO NIIDA
Central Research Laboratories, Meiji Seika, Kaisha Ltd.
KOJI WATANABE
Pharmaceutical Development Laboratories, Meiji Seika Kaisha Ltd.

JOURNAL FREE ACCESS

1981 Volume 34 Issue 9 Pages 1090-1100

DOI https://doi.org/10.7164/antibiotics.34.1090

Details

Abstract

A new aminoglycoside antibiotic, dactimicin produced by a Dactylosporangium matsuzakiense SF-2052 has been isolated by column chromatography on a cation-exchange resin and CM-Sephadex. The structure of dactimicin was determined to be 4-amino-1, 4-dideoxy- 3 - O - (2, 6 - diamino-2, 3, 4, 6, 7 -pentadeoxy- β- L -lyxo-heptopyranosyl)-1-[(N-formimidoylglycyl)- methylamino]-6-O-methyl-L-chiro-inositol. Alkaline hydrolysis of dactimicin afforded 1-N -(N-formylglycyl)fortimicin B, fortimicin B, fortimicin A and an acyl migration product, 2'-N-(N-formylglycyl)fortimicin B.

Corresponding author

Register with J-STAGE for free!