The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
STUDIES ON A NEW AMINOGLYCOSIDE ANTIBIOTIC, DACTIMICIN
II. ISOLATION, STRUCTURE AND CHEMICAL DEGRADATION
KAZUNORI OHBATAKASHI TSURUOKAKAZUKO MIZUTANINORIKO KATOSHOJI OMOTONORIO EZAKISHIGEHARU INOUYETARO NIIDAKOJI WATANABE
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1981 Volume 34 Issue 9 Pages 1090-1100

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Abstract

A new aminoglycoside antibiotic, dactimicin produced by a Dactylosporangium matsuzakiense SF-2052 has been isolated by column chromatography on a cation-exchange resin and CM-Sephadex. The structure of dactimicin was determined to be 4-amino-1, 4-dideoxy- 3 - O - (2, 6 - diamino-2, 3, 4, 6, 7 -pentadeoxy- β- L -lyxo-heptopyranosyl)-1-[(N-formimidoylglycyl)- methylamino]-6-O-methyl-L-chiro-inositol. Alkaline hydrolysis of dactimicin afforded 1-N -(N-formylglycyl)fortimicin B, fortimicin B, fortimicin A and an acyl migration product, 2'-N-(N-formylglycyl)fortimicin B.

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© Japan Antibiotics Research Association
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