The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
STUDIES ON A NEW IMMUNOACTIVE PEPTIDE, FK-156
II. FERMENTATION, EXTRACTION AND CHEMICAL AND BIOLOGICAL CHARACTERIZATION
TOSHIO GOTOH, KUNIO NAKAHARA, TOYOJI NISHIURA, MASAHARU HASHIMOTO, TORU KINO, YOSHIO KURODA, MASAKUNI OKUHARA, MASANOBU KOHSAKA, HATSUO AOKI, HIROSHI IMANAKA
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1982 年 35 巻 10 号 p. 1286-1292

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An interesting immunoactive peptide, FK-156, has been isolated from the fermentation broth of Streptomyces olivaceogriseus sp. nov. and Streptomyces violaceus. The compound was purified by column chromatography with activated carbon, ion exchange Sephadex and cellulose powder. FK-156, obtained as white powder, exhibits a wide variety of immunostimulatory activity in vivo and in vitro with experimental animals. Pretreatment of mice or rats with this peptide protected the animals against lethal infection with Escherichia coli and resulted in prolongation of life span of tumor bearing animals.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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