A GENETIC APPROACH TO THE BIOSYNTHESIS OF THE RIFAMYCIN-CHROMOPHORE IN NOCARDIA MEDITERRANEI
V. STUDIES ON THE BIOGENETIC ORIGIN OF 3-SUBSTITUENTS
1982 年 35 巻 10 号 p. 1361-1366
詳細
1982 年 35 巻 10 号 p. 1361-1366
4-Substituted 3-amino-5-hydroxybenzoic acids were tested in mutasynthesis experiments as potential starter-units for the biosynthesis of 3-substituted rifamycins. From our results it can be concluded that 3-substituents in rifamycin and other ansamycin chromophores must be introduced in a late biosynthetic step.
