FERENSIMYCINS A AND B, TWO POLYETHER ANTIBIOTICS

TAXONOMY, FERMENTATION, ISOLATION, CHARACTERIZATION AND STRUCTURAL STUDIES

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Ferensimycin A* (I), C₃₄H₅₉O₁₀Na, mp 133-135°C, and ferensimycin B** (II), C₃₅H₆₁O₁₀Na, mp 143-145°C, were isolated as their sodium salts from the fermentation broth of Streptomyces sp. No. 5057, a strain similar to Streptomyces myxogenes Shomura et al. The physicochemical data of I and II showed that they are both closely related congeners of lysocellin (III). Ferensimycins A and B exhibit activity against Gram-positive bacteria and are effective in the treatment of coccidiosis of fowl.