LEPTOMYCINS A AND B, NEW ANTIFUNGAL ANTIBIOTICS

I. TAXONOMY OF THE PRODUCING STRAIN AND THEIR FERMENTATION, PURIFICATION AND CHARACTERIZATION

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A strain of Streptomyces was found to produce new antifungal antibiotics. The active compounds were purified and separated into two substances named leptomycin A and B by high performance liquid chromatography. The molecular formulae of leptomycins A and B are C₃₂H₄₆O₆ and C₃₃H₄₈O₆ respectively, and physicochemical and biological properties of them are very similar to each other. Leptomycins A and B exhibit strong inhibitory activity against Schizosaccharomyces and Mucor.