MYCOPLANECINS, NOVEL ANTIMYCOBACTERIAL ANTIBIOTICS FROM ACTINOPLANES AWAJINENSIS SUBSP. MYCOPLANECINUS SUBSP. NOV.

III. STRUCTURAL DETERMINATION OF MYCOPLANECIN A

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The structure of mycoplanecin A was determined by the analysis of chemical degradation products and by mass and ¹H and ¹³C NMR spectrometries. Mycoplanecin A is a new cyclic peptide antibiotic composed of mol each of α-ketobutyric acid, glycine, L-leucine, L-proline, L-2-amino-5-methylhexanoic acid, N-methyl-D-leucine, N-methyl-L-threonine, methyl-L-proline and ethyl-L-proline and two mol of N-methyl-L-valine. Among these components, ethyl-L-proline is reported for the first time as a component of natural products. A newly developed mass analysis has been introduced for the differentiation of α-amino acid and its N-methyl derivative.