NEW α-AMYLASE INHIBITOR, TRESTATINS I. ISOLATION, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF TRESTATINS A, B AND C

KAZUTERU YOKOSE; KIYOSHI OGAWA; TAKASHI SANO; KIMIHIRO WATANABE; HIROMI B. MARUYAMA; YASUJI SUHARA

doi:10.7164/antibiotics.36.1157

NEW α-AMYLASE INHIBITOR, TRESTATINS

I. ISOLATION, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF TRESTATINS A, B AND C

KAZUTERU YOKOSE, KIYOSHI OGAWA, TAKASHI SANO, KIMIHIRO WATANABE, HIROMI B. MARUYAMA, YASUJI SUHARA

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ジャーナルフリー

1983 年 36 巻 9 号 p. 1157-1165

DOI https://doi.org/10.7164/antibiotics.36.1157

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抄録

Trestatin complex which exhibited a potent inhibitory activity on various α-amylases has been isolated from the culture filtrate of Streptomyces dimorphogenes nov. sp. NR-320-OM7HB. Three major components, trestatins A, B and C, have been purified by adsorption and ion-exchange chromatography. Their spectral and chemical properties suggested that trestatins were novel basic oligosaccharide homologues each characterized by the possession of a trehalose moiety at the non-reducing end of the molecule.

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